Zebra mussel control methods include both preventive and reactive strategies. Preventive control methods include antifouling coatings, chemical use, and thermal treatment. Reactive control methods are mechanical cleaning, high pressure water jetting, carbon dioxide pellet blasting, freezing, and desiccation. Chemical and thermal treatments can be used as a reactive treatment to clean a system, then preventively as regular maintenance to prevent further fouling. These options, along with new designs, retrofit, and future control techniques are reviewed in this chapter. Selection of appropriate control methods should be based on environmental and economic factors, ease of application, and the nature of the application.